
ALG-2InteractingProtein-X(ALIX)MonoclonalAntibody
ALG-2-interactingprotein-X(ALIX),alsoknownasAIP1,isacytoplasmicproteinubiquitouslyexpressedandconcentratedinphagosomesandexosomes.ALIXmayregulateapoptosissinceitbindsapoptosis-linkedgene2(ALG-2),aCa2+-bindingproteinnecessaryforcelldeath.InhibitingALG-2expressionprotectscellsfromdeathinducedbyseveralstimuli,aneffectsimilartothatseenwithoverexpressionoftheC-terminalhalfofALIXwhichcontainstheALG-2-interactingdomain.
ThisantibodyrecognizeshumanALIXprotein.
APPLICATIONSImmunoblotting:useat1-5ug/ml.Abandof~96kDaisdetected.
Immunohistochemistry:useat5-10ug/ml.
Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.
Reconstituteindistilledwater.
Thisproductisstableforatleastone(1)yearat-20oCto-70oC.Reconstitutedproductshouldbestoredinappropriatealiquotstoavoidrepeatedfreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.