Anti-DcR3(NT)Antibody
CatalogNo.:2140
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychromatography.
SeveralnovelmembersintheTNFreceptorfamily,includingDR3,DR4,DR5andDR6,functionascelldeathreceptors.Twodecoyreceptors,DcR1andDcR2,competewithDR4andDR5forbindingoftheirligand,TRAIL.Anotherdecoyreceptor,DcR3/TR6wasdiscoveredrecently.UnlikeDcR1andDcR2,DcR3isasolubleratherthanamembrane-associatedmolecule.DcR3bindstoFasLandLIGHTandinhibitsFasL-andLIGHT-inducedapoptosis.DcR3transcriptisexpressedinsomelungandcoloncarcinomasandinsomenormaltissues.
Antigen:Peptidecorrespondingtoaa31-46ofhumanDcR3precursor(accessionno.
AF104419).
HostSpecies:Rabbit
StABIlizers:None
Preservatives:0.02%sodiumazide.
Thisantibodyrecognizeshuman,mouse,andratDcR3(33kDa).
APPLICATIONSImmunoblotting:useat1ug/ml.
WesternblotanalysisofDcR3inhumanheart(H),brain(B),andkidney(K)tissuelysateswithDcR3antibodyat1μg/ml.
Immunohistochemistry:
ImmunohistochemicalstainingofDcR3inhumanhearttissuewithDcR3antibodyat1μg/ml.
Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.
Positivecontrol:Humanhearttissuelysate.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
