Anti-DR3(CT)Antibody
CatalogNo.:2403
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychromatography.
ApoptosisisinducedbycertaincytokinesincludingTNFandFasligandoftheTNFfamilythroughtheirdeathdomain-containingreceptors,TNFR1andFas.AnothercelldeathreceptorhasbeenidentifiedanddesignatedDR3,Wsl-1,Apo-3,TRAMP,andLARD.DR3iswidelyexpressedintissuesenrichedinlymphocytesincludingperipheralblood,thymus,andspleen.LikeTNFR1,DR3inducesapoptosisandNF-Bactivation.
Antigen:Peptidecorrespondingtoaa398-417ofhumanDR3(accessionno.AAQ88676).
HostSpecies:Rabbit
StABIlizers:None
Preservatives:0.02%sodiumazide.
Thisantibodyrecognizesfull-lengthhumanDR3(59kDa).
APPLICATIONSImmunoblotting:useat2ug/ml.
WesternblotanalysisofDR3inJurkatcelllysatewithanti-DR3(CT)at2ug/ml.
Positivecontrol:WholecelllysatefromJurkatcells.
Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
