CatalogNo.:2402

Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychromatography.

ApoptosisisinducedbycertaincytokinesincludingTNFandFasligandoftheTNFfamilythroughtheirdeathdomain-containingreceptors,TNFR1andFas.AnothercelldeathreceptorwasrecentlyidentifiedanddesignatedDR3,Wsl-1,Apo-3,TRAMP,andLARD.

DR3iswidelyexpressedintissuesenrichedinlymphocytesincludingperipheralblood,thymus,andspleen.LikeTNFR1,DR3inducesapoptosisandNF-Bactivation.

Antigen:Peptidecorrespondingtoaa25-40attheN-terminusofhumanDR3(accessionno.AAQ88676).

HostSpecies:Rabbit

StABIlizers:None

Preservatives:0.02%sodiumazide.

Thisantibodyrecognizesfull-lengthhumanandmouseDR3(59kDa).

Immunoblotting:useat1ug/ml.

WesternblotanalysisofDR3inJurkatcelllysatewithanti-DR3(NT)at1ug/ml.

Positivecontrol:WholecelllysatefromJurkatcells.

Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.