Anti-TRICK2(DR5,TRAIL-R2)Antibody
CatalogNo.:11091
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychromatography.
ApoptosisisinducedbycytokinesintheTNFfamilythroughtheirdeathdomaincontainingreceptors.TRICK2(TRAILreceptorinducerofcellkilling2)isamemberoftheTNFreceptorfamilyandcontainstheconserveddeathdomain.TRICK2isexpressedathighlevelsinlymphocytesandspleencellsandinmanytypesoftumorcells.OverexpressionofTRICK2rapidlyinducescelldeathbyapoptosis.TRICK2hasbeenshowntofunctionasareceptorforTRAILandcaninhibitTRAIL-inducedkillingoflymphocyticcells.OthernamesforTRICK2includeDR5,Apo2,TRAIL-R2,andKILLER.
Immunogen:Syntheticpeptidecorrespondingtoaminoacids409-427(LGERLAKQKIEDHLLSSGK,isoform1)of
humanTRICK2precursorconjugatedtoKLHattheN-terminus.Thesamesequence
isfoundataminoacids380-398inisoform2.
HostSpecies:Rabbit
StABIlizers:None
Preservatives:None.Availableonrequest.
SPECIFICITYThisantibodyrecognizeshumanTRICK2.
Immunoblotting:usea1:500dilution.Abandofapproximately57kDaisdetected.
Positivecontrol:wholecelllysatefromHL60,HeLa,orJurkatcells.
Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
