productdatasheet

CatalogNo.:11092

Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.

ApoptosisisinducedbycytokinesintheTNFfamilythroughtheirdeathdomaincontainingreceptors.TRICK2(TRAILreceptorinducerofcellkilling2)isamemberoftheTNFreceptorfamilyandcontainstheconserveddeathdomain.TRICK2isexpressedathighlevelsinlymphocytesandspleencellsandinmanytypesoftumorcells.OverexpressionofTRICK2rapidlyinducescelldeathbyapoptosis.TRICK2hasbeenshowntofunctionasareceptorforTRAILandcaninhibitTRAIL-inducedkillingoflymphocyticcells.OthernamesforTRICK2includeDR5,Apo2,TRAIL-R2,andKILLER.

Screaton,GRetal.(1997)CurrBiol7:693-696.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

Immunogen:Syntheticpeptidecorrespondingtoaminoacids309-325(EHLLEPAEAERSQRRRL,isoform1)ofhumanTRICK2precursorconjugatedtoKLHattheN-terminus.Thesamesequenceisfoundinisoform2ataminoacids280-296.

HostSpecies:Rabbit

StABIlizers:NonePreservatives:None.Availableonrequest.

ThisantibodyrecognizeshumanTRICK2.

Immunoblotting:useat1:500dilution.Abandofapproximately57kDaisdetected.

Positivecontrol:wholecelllysatefromHL60,HeLa,orJurkatcells.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone

(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.