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CatalogNo.:3310

Size:100ugor200ugProteinG-purifiedantibodyinPBS,pH7.4

Antigen:GSTfusionproteinexpressedinE.colicorrespondingtoaa2577-3056offull-lengthATM.

HostSpecies:MouseAntibodyClass:IgG1/κStABIlizers:None

Preservatives:None.Availableonrequest.

Thisantibodyrecognizesfull-lengthATM,a370kDnuclearphosphoprotein,whichisinvolvedintheautooalrecessivediseaseataxiatelangiectasia(AT).ATMbelongstoanovelfamilyofproteinsassociatedwithcellcycleregulationandresponsetoDNArepair.TheC-terminalregionhasextensivehomologytothecatalyticdomainsofphosphatidylinositol3-kinases(PI3kinases).ItsusefulnesstomonitoralteredATMexpressionincancerisunderactiveinvestigations.

Immunoblotting:useat1-10ug/ml.Immunoprecipitation:useat1-10ug/ml.Positivecontrols:RajiorAkatacells.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone

(1)yearat-70oC.Avoidmultiplefreeze-thawcycles.

Chen,GandEY-HPLee(1996)JBiolChem271:33693-33697.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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