productdatasheet
CatalogNo.:56221
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychromatography.
Antigen:Peptidecorrespondingtoaa2-18ofhumanChk2.
HostSpecies:Rabbit
StABIlizers:None
Preservatives:0.02%sodiumazide
ThisantibodyrecognizesanepitopeattheN-terminusofhuman,mouse,andratChk2(CheckpointKinase2).InresponsetoDNAdamage,ATMphosphorylatesandactivatesChk2whichinturndirectlyphosphorylatesandactivatesp53.Chk2alsophos-phorylatesandactivatesBRCA1,theproductofatumorsuppressorgenethatisoftenmutatedinbreastandovariancancer.
APPLICATIONSImmunoblotting:useat0.5-1ug/ml.Inimmunoblots,abandof60kDisdetected.
Positivecontrol:Jurkatcelllysate.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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