productdatasheet

CatalogNo.:34005

Size:100ugIgGin100ul(1mg/ml)PBS.

Epithelium-specificgeneregulationplaysacriticalroleduringembryogenesis,andtheepithelialcelllineageisthefirstdifferentiatedcelltypetoappearafterfertilization.Untilrecently,veryfewepithelialcell-restrictedtranscriptionfactorshadbeendescribed.Membersoftheetstranscriptionfactor/oncogenefamilyhavebeenimplicatedinhumancarcinogenesisfollowingthediscoveryofseveraldistinctchromosomaltranslocationsinvolvingmembersoftheetsfamilyindifferenttypesofcancer.etsfactorsplaykeyrolesintranscriptionalcontrolofstringentlyregulatedgenes,suchasgenesinvolvedintissuedevelopment,differentiation,angiogenesis,cellcyclecontrolandcellproliferation.ESE-1isthefirstmemberoftheetsfamilythatwasfoundtobeexclusivelyexpressedandinducIBLeinepithelialcells.

Antigen:N-terminalsequenceMAATCEISNIFSNYFSandC-terminalsequenceSSGWKEEEVLQSRNofhumanESE-1protein.

HostSpecies:Rabbit

Preservatives:0.02%sodiumazide.

ThisantibodyrecognizeshumanESE-1(39-41kD).

Immunoblotting:useat1:500-1:1,000dilution.

ELISA:useat1:1,000-1:5,000dilution.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.