productdatasheet

CatalogNo.:3336

Size:100ugProteinG-purifiedantibodyinPBS,pH7.4

Antigen:6-Hisfusionproteincontainingtheregionencodingaa1-153ofhumanestrogenreceptor-β

(ER-β)expressedinE.coli.

HostSpecies:MouseAntibodyClass:IgG2b/κStABIlizers:None

Preservatives:None.Availableonrequest.

ThisantibodyrecognizeshumanER-β,anovelreceptor(approx.52kD)recentlyisolatedfromtestis.ThesizeandstructureofER-βareverysimilartoER-αwiththeligandandDNAbindingdomainsbeinghighlyconserved.TheN-terminusofeachreceptor,whichservesastheirtransactivationdomain,aresignificantlydifferent.LikeER-α,ER-βbindstoestrogenwithahighaffinityandregulatesestrogen-specificgeneactivationthroughdirectinteractionwithestrogenresponseelements.

Immunoblotting:useat1-5ug/ml.Positivecontrols:Nativereceptorfromhumanthymus,spleen,ovary,andtestisorrecombinantprotein.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone

(1)yearat-70oC.Avoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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