productdatasheet

CatalogNo.:34008

Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.

Hippostatin,alsoknownasKLK11,isakallikrein-likeserineprotease,whichhastwoalternativelysplicedisoforms,brain-typeandprostate-type.Hippostatinplaysaroleintheprostate,includingreproductiveand/ortumOrigenicfunctions.ElevatedserumlevelsofKLK11werefoundin70%ofwomenwithovariancancerandin60%ofmenwithprostatecancer.AnalysisoftheKLK11bioMarkerinserummayaidinthediagnosisandmonitoringofovarianandprostaticcarcinoma.

Immunogen:Syntheticpeptidecorrespondingtoaaresidues68-82(YIVHLGQHNLQKEEG)ofhuman

HippostatinconjugatedtoKLHattheC-terminus.

HostSpecies:Rabbit

StABIlizers:NonePreservatives:None.Availableonrequest.

Thisantibodyrecognizeshumanhippostatin/KLK11(35kDa)whichhas86%sequencehomologywithmouseandrat.

Immunoblotting:useat1:500dilution.

Positivecontrol:LNCaPcelllysate

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone

(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.

Diamandis,E.P.etal.(2002)CancerRes.62:295-300.

Nakamura,Tetal.(2003)Prostate54:

299-305.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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