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当前位置: 首页 > 产品中心 > antibody > QED生物科学/MLL(N端)/34041/1 Ea
商品详细QED生物科学/MLL(N端)/34041/1 Ea
QED生物科学/MLL(N端)/34041/1 Ea
QED生物科学/MLL(N端)/34041/1 Ea
商品编号: 34041
品牌: qedbio
市场价: ¥6740.00
美元价: 4044.00
产地: 美国(厂家直采)
公司:
产品分类: 抗体
公司分类: antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍


Anti-MLLN-TerminusMonoclonalAntibody


ORDERINGINFORMATIONCatalogno.:34041Size:100ugProteinG-purifiedantibodyinPBS,pH7.4.


BACKGROUND

MLL(MixedLineageLeukemia)isaproto-oncogenethatismutatedinavarietyofacuteleukemias.MLLisproteolyticallyprocessedinto2fragments,MLLNandMLLC,thatdisplayoppositetranscriptionalproperties.ProcessedMLLNandMLLC

associatewitheachotherviaN-terminalandC-terminalintramolecularinteractiondomains.MLLprocessingoccursrapidlyaftertranslationandisfollowedby

phosphorylationofMLLC.MLLNdisplays

transcriptionalrepressionactivity,whereasMLLChasstrongtranscriptionalactivationproperties.Leukemia-associatedMLLfusionproteinslacktheMLLprocessingsites,donotundergocleavage,andareunabletointeractwithMLLC.These

observationssuggestthatposttranslationalmodificationsofMLLmaybeinvolvedinregulatingMLLactivityasatranscriptionfactor,andthisaspectofitsfunctionisperturbedbyleukemogenicfusions.


SPECIFICATIONSUMMARYAntigen:Maltose-bindingfusionproteincontainingMLLaminoacids161-356(Uniprot#Q03164).Cloneno.:N4.4Host:MouseAntibodyClass:IgG1Preservatives:None-availableonrequest.


SPECIFICITY

ThisantibodyrecognizeshumanandmouseMLLN.

APPLICATIONS

Immunoblotting:useat2ug/ml.Abandof

~300kDaisdetected.


K562cellnuclearextractwith#34041at2ug/ml.


Immunoprecipitation:use2-10ugper500ul(1-3mg/ml)ofcelllysate.

Thesearerecommendedconcentrations.Endusersshoulddetermineoptimalconcentrationsfortheirapplications.

Positivecontrol:K562celllysate.


DILUTIONINSTRUCTIONS

DiluteinPBSormediumthatisidenticaltothatusedintheassaysystem.


STORAGEANDSTABILITY

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.


PRODUCTREFERENCES

YokoyamaAetal.2002Blood100:3710-

3718.

YokoyamaAetal.2005Cell123:207-218.


Forinvitroinvestigationaluseonly.Notintendedfordiagnosticortherapeuticapplications.

品牌介绍
QEDBioscience已经设计和制造抗体超过20年,QEDBioscience的目标保持不变:提供市场上最好的抗体产品和服务,并为QEDBioscience的客户提供他们期望的全面的专业知识和帮助。频谱抗体公司如QED。QEDBioscience为我们的学术,生物技术,诊断和药物研究客户开发新型单克隆和多克隆抗体产品。QEDBioscience使用客户的小分子,蛋白质或肽靶标或利用靶CDNA开发这些抗体,是一家提供全方位服务的公司,并提供额外的免疫化学服务,如纯化和结合,以便我们能够为客户提供一种特异于其系统的抗体产品。我们还开发了具有酶中和和抑制受体-配体相互作用以及抗独特型抗体的药理活性的单克隆抗体。