productdatasheet

CatalogNo.:56211

Size:100ugProteinG-purifiedantibodyinPBS,pH7.4

Antigen:GSTfusionproteincorrespondingtoaa182-582ofMre11expressedinE.coli.

HostSpecies:MouseAntibodyClass:IgG1/κStABIlizers:None

Preservatives:None.Availableonrequest.

ThisantibodyrecognizeshumanMre11,an80kDproteinthatactsasaMn+2-dependentdoublestrandedDNA3’to5’exonucleaseandasinglestrandedDNAendonuclease.ItispartofalargercomplexwithRad50,p95(Nibrin),andpossIBLyotherproteinsinvolvedinthenucleolyticend-processingofdoublestrandbreaksandtelomeremaintenance.

Immunoblotting,immunoprecipitation:useat1-5ug/ml.

Positivecontrol:T24cells,recombinantfusionprotein.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone

(1)yearat-70oC.Avoidmultiplefreeze-thawcycles.

Trujillo,KMetal.1998.JBiolChem273:21447-21450;Carney,JPetal.

1998.Cell93:477-486;Moreau,Set

al.1999.MolCellBiol19:556-566.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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