
MyoferlinMonoclonalAntibody
Ferlinproteinshavebeenimplicatedinvesicletraffickinginavarietyofphysio-logicalsettings.AllmammalianferlinsderivetheirnamesbasedonhomologytotheC.elegansproteinFER-1(FERtilizationdefective-1).FER1L3(myoferlin,MYOF),hasnotyetbeendirectlyassociatedwithadistinctmammaliandisorder,butrecentmicroarrayandproteomicstudiesinthecancerliteraturehavereportedoverexpressionofMYOFinbreastcancerspecimensandrelevantcelllines.Therefore,MYOFmaybeanimportantproteininbreastcancercellsfortheirmobilizationduringcellularmigrationand/orinvasion.
ThisantibodyrecognizeshumanandmouseFER1L3.
Immunoblotting:useat1-10ug/ml.Abandof~230kDaisdetected.
Detectionofmyoferlinin(1)C2C12celllysateand(2)humanfibroblastcelllysatewith#90020.
Immunocytochemistry:useat1-20ug/ml.
Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.
Reconstituteindistilledwater.
Thisproductisstableforatleastone(1)yearat-20oCto-70oC.Reconstitutedproductshouldbestoredinappropriatealiquotstoavoidrepeatedfreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.