productdatasheet

CatalogNo.:34013

Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.

NKX3.1isahomeoboxgenewhichexhibitsprostate-andtestis-specificexpression.LossofNKX3.1expressionhasbeenimplicatedinprostatedevelopmentandtumOrigenesis.NKX3.1expressionisdramaticallydown-regulatedintesticularcancerofgermcellorigin.ResultssuggestthatNKX3.1isessentialfornormaltestisfunctionandthatitslossofexpressionishighlyassociatedwiththeinvasivephenotypeoftesticulargermcelltumors.

Immunogen:Syntheticpeptidecorrespondingtoaaresidues21-37(TPSKPLTSFLIQDILRD)ofhuman

NKX3.1conjugatedtoKLHattheC-terminus.

HostSpecies:Rabbit

StABIlizers:NonePreservatives:None.Availableonrequest.

ThisantibodyrecognizeshumanNKX3.1(approx.26kDa).Thissequenceishighlyconservedinratandmouse.

Immunoblotting:useat1:1,000Positivecontrol:Humanprostatetissueextracts.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone

(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.

LindGE.etal.(2005)MolCancer.4:8.GelmannE.P.etal.(2003)Prostate55:111-117.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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