productdatasheet
CatalogNo.:56223
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychromatography.
Antigen:Peptidecorrespondingtoaa1-14ofhumanp53DINP1.Thissequenceisidenticalinp53DINP1αandβanddiffersfromthatofmousep53DINP1byoneaminoacid.
HostSpecies:Rabbit
StABIlizers:None
Preservatives:0.02%sodiumazide
Thisantibodyrecognizeshuman,mouse,andratp53DINP1(p53-DependentDamage-InducIBLeNuclearProtein1),ap53induciblegene.Ap53DINP1antisenseoligonucleotideinhibits,andoverexpressionofp53DINP1enhances,Ser46phos-phorylationofp53,inductionofp53AIP1,andcelldeathinducedbyDNAdouble-strandbreaks.Thep53DINP1geneencodestwoproteinsof27and18kDdesignatedp53DINP1-αandp53DINP1-β.p53DINP1is
expressedinmanytissuesandisinducedbystressagents.
Immunoblotting:useat1-2ug/ml.Inimmunoblotsonhumanlungtissuelysate,abandof27kDisdetected.Alowermolecularweightbandisdetectedat18kDinhumanspleenandmouseliverandkidneytissuelysateswhichprobablyrepresentsp53DINP1-β.
Positivecontrol:Humanlungtissue
lysate.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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