productdatasheet
CatalogNo.:34012
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.
PDRG(p53andDNAdamage-regulatedgene)ispredominantlyexpressedinnormalhumantestisbutcanbedetectedatlowerlevelsinotherorgans.PDRGmRNAisupregulatedafterexposureofcellstoUVrADIationbutisdownregulatedbytumorsuppressorp53.SequenceanalysisofPDRGpromoterrevealedthepresenceofanOct-1bindingsiteaswellasap53bindingsite.PDRGisanovelgeneinthatitisdifferentiallyregulatedbyp53andUVradiation.
Immunogen:SyntheticpeptidecorrespondingtotheaasequenceCDHLDKEIEKLRKQLKofhumanPDRG
conjugatedtoKLH.HostSpecies:RabbitStABIlizers:None
Preservatives:None.Availableonrequest.
SPECIFICITYThisantibodyrecognizeshumanandmousePDRG(approx15kDa).
Immunoblotting:useat1:500-1:1,000dilution.
Positivecontrol:Normalhumanormousetestis.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
LuoXetal.2003Oncogene22:7247-
57.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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