productdatasheet
CatalogNo.:56227
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychromatography.
Antigen:Peptidecorrespondingtoaa652-668ofhumanPID/MTA2.Thissequencediffersfromthatofmousebyoneaminoacid.
HostSpecies:Rabbit
StABIlizers:None
Preservatives:0.02%sodiumazide
Thisantibodyrecognizeshuman,mouse,andratPID/MTA2,asubunitofthenucleosomeremodelinganddeacetylating(NRD/NuRD)complex.PID/MTA2modulatestheenzymaticactivityofthehistonedeacetylasecomplex,anditsexpressionreducesthelevelsofacetylatedp53.Deacetylationofp53byPID/MTA2repressesp53-dependenttranscriptionalactivationandmodulatesp53-mediatedcellgrowtharrestandapoptosis.PID/MTA2isexpressedinavarietyoftissues.Thisantibodydoesnotcross-reactwithMTA1.
APPLICATIONSImmunoblotting:useat0.5-1ug/ml.Inimmunoblots,abandof75kDisdetected.
Positivecontrol:HeLacelllysate.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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