productdatasheet

CatalogNo.:3341

Size:100ugProteinG-purifiedantibodyinPBS,pH7.4

Antigen:6-Hisfusionproteincontainingtheregionencodingaa1-101ofhumanprogesteronereceptorexpressedinE.coli.

HostSpecies:MouseAntibodyClass:IgG2a/κStABIlizers:None

Preservatives:None.Availableonrequest.

Thisantibodyrecognizeshumanprogesteronereceptor(PgR),amemberofthesteroidfamilyofnuclearreceptors.PgRisfoundasa94kDprotein(FormA)ora120kDprotein(FormB).Bindingofprogesteronetoitsreceptorresultsinaconformationalchangethatallowsdimerizationandbindingofthereceptortoprogesteroneresponseelementsandactivatedtranscription.WhenboundtoDNA,

PgRcanpositivelyornegativelyregulategenetranscription.

Immunoblotting:useat1-5ug/ml.Positivecontrols:MCF7cellsorrecombinantprotein.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone

(1)yearat-70oC.Avoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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