productdatasheet
CatalogNo.:34024
Size:50ulascitesfluidcontaining0.1%sodiumazide.Antibodyconcentrationapprox.3mg/ml.
Telomeraseisareversetranscriptasethataddstelomericrepeats(TTAGGG)tochromosomeends.Innormalsomaticcells,telomeraseisnotactiveandtelomeresprogressivelyshorten,leADIngtolimitedcellLifespanandsenescence.Activationoftelomeraseisassociatedwithhumancancersandcellimmortalization.Humantelomeraseiscomprisedofthreemajorsubnunits:acatalyticsubunit(hTERT),atemplateRNA(hTR),andtelomerase-associatedprotein(TEP-1).TranscriptionofTERTistheprimarymechanismforregulatingtelomeraseactivity.
Antigen:Full-lengthrecombinanthTERTexpressedininsectcells.HostSpecies:Mouse
CloneNo.:2D8
AntibodyClass:IgM
Preservatives:0.1%sodiumazide
SPECIFICITYThisantibodyrecognizeshumanTERT;specificepitopenotdetermined.
Immunoblotting,immunoprecipitation:
Useat1:500-1:1,000dilution.Immunohistochemistry:Useat1:1,000dilution.
Lung,bronchiole:Formalin-fixed,paraffin-embedded.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableat4oC(short-term)and-70oC(long-term).
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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