productdatasheet
CatalogNo.:34026
Size:50ugimmunogenaffinitypurifiedantibodyinPBScontaining0.02%sodiumazide.
Telomeraseisareversetranscriptasethataddstelomericrepeats(TTAGGG)tochromosomeends.Innormalsomaticcells,telomeraseisnotactiveandtelomeresprogressivelyshorten,leADIngtolimitedcellLifespanandsenescence.Activationoftelomeraseisassociatedwithhumancancersandcellimmortalization.Humantelomeraseiscomprisedofthreemajorsubnunits:acatalyticsubunit(hTERT),atemplateRNA(hTR),andtelomerase-associatedprotein(TEP-1).TranscriptionofTERTistheprimarymechanismforregulatingtelomeraseactivity.
Antigen:SyntheticpeptideconjugatedtoKLH
HostSpecies:Rabbit
Preservatives:0.02%sodiumazide
Thisantibodyrecognizesanepitopewithin20aminoacidsneartheaminoterminusofhumanTEP-1.
Immunoblotting:Useat5ug/ml.
Immunohistochemistry:Useat5ug/ml.
Skin:Formalin-fixed,paraffin-embedded
Breast:Formalin-fixed,paraffin-embedded
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableat4oC(short-term)and-70oC(long-term).
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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