productdatasheet
CatalogNo.:34031
Size:100ugProteinG-purifiedantibodyinPBS,pH7.4.
BACKGROUNDAubiquitouslyexpressedgenedesignatedTERE1(TransitionalEpithelialResponseGene1),whichmapstochromosome1p36.11-1p36.33,hasasignificanteffectongrowthregulationofbladdercancerandmayplayanequallysignificantroleingrowthregulationofprostatecancer.TheTERE1geneislocatedbetweenthemicro-satelliteMarkersD1S2667andD1S434,achromosomelocusthathasbeenidentifiedasasiteofatumorsuppressorgeneorgenesformultipletumortypes.InducedTERE1expressionintwoprostatecarcinomacelllines,LNCaPandPC-3,decreasedproliferationupto80%withasignificantincreaseinthenumberofcellsinG1.TheTERE1transcriptispresentinmostnormalhumantissues,butisreducedorabsentinthemajorityofmuscleinvasiveTCC(TransitionalCellCarcinomaofthebladder)tumors.
Immunogen:Syntheticpeptidecorrespondingtoaminoacids32-45ofhumanTERE1.Thissequenceis85%homologouswithmouseandrat.
HostSpecies:Rabbit
AntibodyClass:PolyclonalPreservatives:None.Availableonrequest.
ThisantibodyrecognizeshumanTERE1.Otherspecieshavenotbeentested.
Immunoblotting:useat1-5ug/ml.Abandofapproximately37kDais
detected.Thesearerecommendedconcentrations.Usershoulddetermineoptimalconcentrationsfortheirapplications.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
QEDBioscience,Inc.10919TechnologyPlace,SuiteC
SanDiego,CA92127
TollFree800.929.2114
Phone858.675.2405
Fax858.592.1509
info@qedbio.com
Visitourwebsiteforadditionalproductinformationandtoorderonline.
qedbio.com
