productdatasheet
CatalogNo.:34016
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.
WWdomain-containingoxidoreductase,WWOX,alsoknownasWOX1orFOR,isaproapoptoticproteinexpressedbyatumorsuppressorgene.BecausemutationordeletioninthecodingregionofWWOXisrarelyfound,itisspeculatedthattheappearanceofaberranttranscriptsaffectsprogressionofmanycancers.Inaddition,proteinlevelsofWWOX,itsTyr33-phosphorylatedform,andWOX2aresignificantlydown-regulatedintheneuronsofAlzheimer’shippocampi.
Immunogen:Syntheticpeptidecorrespondingtoaminoacids89-107(RLAFTVDDNPTKPTTRQRY)ofhuman
WWOXconjugatedtoKLHattheC-terminus.
HostSpecies:RabbitStABIlizers:NonePreservatives:None.Availableonrequest.
SPECIFICITYThisantibodyrecognizeshumanandmouseWWOX.SequenceidentitytochimpanzeeandorangutanWWOXis100%.
Immunoblotting:useat1:5,000dilution.Abandofapproximately46kDaisdetected.
Positivecontrol:MCF-7humanbreastcancercelllysateormurinefibroblastL929celllysate.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Chang,N.Setal.Oncogene(2005)24:714-723.
Aqeilan,R.I.etal.CancerRes(2004)64:8256-8261.
Sze,C.I.etal.JBiolChem(2004)279:30498-30506.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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