productdatasheet
CatalogNo.:17301
Size:200ugIgMinPBS,pH7.4.
FK-506isanovelmacrolidewithsimilar,butmorepotent,immunosuppressantactivitythancyclosporine.FK-506isusedforprimaryorrescueimmunosuppressioninpatientsaftersolidorgantransplantation.ClinicallyrelevantsideeffectsofFK-506admiNISTrationarenephrotoxicity,neurotoxicity,diabetesmellitus,andhypertension.MostofthesesideeffectsarerelatedtobloodlevelsofFK-506ratherthandosage.Therefore,therapeuticdrugmonitoringofFK-506isaprerequisitefortherapy.Thewholebloodtargetlevelrangeaimedforinclinicalpracticeis3.0-20.0ng/mlanddependsonthepatient'sliverfunction,thenatureoforgantransplantation,andthetimeaftertransplantation.
SPECIFICATIONSUMMARYAntigen:FK-506conjugatedtobovineserumalbumin.
HostSpecies:MouseMouseIsotype:IgMStABIlizers:None
Preservatives:0.1%sodiumazide.
Thisantibodyrecognizesconjugatedandnon-conjugatedFK-506(Kd=10-9M).
APPLICATIONSThisantibodymaybeusedinELISAandWesternblottingtodetectFK-506.
DILUTIONINSTRUCTIONSDiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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