ORDERINGINFORMATION
CatalogNo. 13701 | CloneNo. 1AT10-105.10 | MAbSubtype IgG2a | Size 100ug,500ug | LibraryPackNo. 137101 | 100ug/clone All4clones |
13702 | 1AT11-210.1 | IgG1 | 100ug,500ug | ||
13703 | 1AT11-209.3 | IgG1 | 100ug,500ug | ||
13704 | 1AT11-213.5 | IgG1 | 100ug,500ug |
Format:ProteinG-purifiedantibodyinPBS,pH7.4.
BACKGROUND
Alpha-1Antitrypsin(α1AT)isaproteaseinhibitoroftheserpinsuperfamily.Itisgenerallyknownasserumtrypsininhibitorandisalsoreferredtoasalpha-1proteinaseinhibitor(α1PI)becauseitinhibitsmultipleproteases.Itprotectstissuesfromproteasesofinflammatorycells,particularlyneutrophilelastase,andhasareferencerangeinbloodof1.5-3.5gram/liter,buttheconcentrationcanrisesignificantlyincasesofacuteinflammation.Initsabsence(suchasinα1ATdeficiency),neutrophilelastaseisfreetobreakdownelastin,whichcontributestotheelasticityofthelungs,resultinginrespiratorycomplicationssuchasemphysema,orCOPD(chronicobstructivepulmonarydisease)inadultsandcirrhosisinadultsorchildren.
SPECIFICATIONSUMMARY
Antigen:Purifiedhumanserumalpha-1-antitrypsin.
HostSpecies:Mouse
Specificity:Theseantibodiesspecificallyrecognizehumanserumalpha-1-antitrypsin.Theydonotcross-reactwithalpha-1-antichymotrypsin.
APPLICATIONS
TheseantibodieshavebeenqualifiedforuseinELISAtodetecthumanα1AT.Endusersshoulddetermineoptimalconcentrationsfortheirapplications.
DILUTIONINSTRUCTIONS
DiluteinPBSormediumthatisidenticaltothatusedintheassaysystem.
STORAGEANDSTABILITY
Theseantibodiesarestableforatleastone(1)yearat-20oCto-70oC.Storeproductinappropriatealiquotstoavoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notintendedforuseintherapeuticordiagnosticprocedures.
