productdatasheet
CatalogNo.:13810
Size:50ugpeptideimmunogenaffinitypurifiedantibodyinPBScontaining0.1%sodiumazide.
Sphingosinekinase(SPHK)phosphorylatessphingosinetoformabioactivelipid,sphingosine1-phosphate(S1P).S1Pisanovellipidmessengerwithbothintracellularandextracellularfunctions.Intracellularly,itregulatesproliferationandsurvivalwhileextracellularlyitisaligandforendothelialdifferentiationgene1(EDG1).ExpressionofSPHK1andsubsequentproductionofS1PpromotestheG1-Stransition,protectscellsfromapoptosis,stimulatesmigrationandangiogenesis,andinducestumorformationinmice.
Antigen:SyntheticpeptideconjugatedtoKLH.
HostSpecies:Rabbit
Preservatives:0.1%sodiumazide
SPECIFICITYThisantibodyrecognizesanepitopewithintheN-terminaldomainofhumanSPHK1.
Immunohistochemistry:Useat10ug/ml.
Adrenal,pheochromocytes:Formalin-fixed,paraffin-embedded
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableat4oC(short-term)and-70oC(long-term).
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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