Transglutaminase-2(TG2)MonoclonalAntibody
Transglutaminase2(TG2)isamulti-domain,multi-functionalenzymethatpost-translationallymodifiesproteinsbycatalyzingtheformationofinter-molecularisopeptidebondsbetweenglutamineandlysineside-chains.ItplaysaroleindiverseBIOLOGicalfunctions,includingextracellularmatrixformation,integrinmediatedsignaling,andsignaltransductioninvolving7-transmembranereceptors.WhilesomeoftherolesofTG2undernormalphysiologicalconditionsremainobscure,theproteinisbelievedtoparticipateinthepathogenesisofseveralunrelateddiseasesincludingceliacsprue,neurodegenerativediseases,andcertaintypesofcancer.
ThisantibodyrecognizesguineapigandhumanTG2.
Immunoblotting:useat1-5ug/ml.Abandof~80kDaisdetected.
DetectionofTG2inhumanerythroctyeswith
#90021.
Immunocytochemistry:useat2-10ug/ml.
Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.
Reconstituteindistilledwater.
Thisproductisstableforatleastone(1)yearat-20oCto-70oC.Reconstitutedproductshouldbestoredinappropriatealiquotstoavoidrepeatedfreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
