CD46/MembraneCofactorProteinMonoclonalAntibody
CD46/MembraneCofactorProteinisatypeImembraneproteinandisaregulatorypartofthecomplementsystem;ithascofactoractivityforinactivationofcomplementcomponentsC3bandC4bbyserumfactorIwhichprotectsthehostcellfromdamagebycomplement.ThisproteinalsoactsasareceptorfortheEdmonstonstrainofmeaslesvirus,humanHerpesvirus-6(HHV-6),andtypeIVpiliofpathogenicNeisseria.Ofinterestisthatmedulloblastoma(amalignantbraintumorcommoninchildhood)specimensexpressahighlevelofCD46.
ThisantibodyrecognizeshumanCD46.
APPLICATIONSImmunohistochemistry:useat1-10ug/ml.
Paraffin-embeddedhumanplacentastainedwith
#90004.
Immunoblotting:useat0.5-1ug/ml.Abandof~44kDaisdetected.AdditionalbandsduetoglycosylationofCD46maybedetected.
ELISA:useat0.1-1ug/mlwithhumanCD46onthesolidphase.
Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.
Reconstituteindistilledwater.
Thisproductisstableforatleastone(1)yearat-20oCto-70oC.Reconstitutedproductshouldbestoredinappropriatealiquotstoavoidrepeatedfreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.