EpidermalGrowthFactor-likeProtein7MonoclonalAntibody
EGF-L7(EpidermalGrowthFactorLikeProtein7)isamulti-domainproteincontainingtwoEGFlikedomainsandoneEMIdomain.Itisexpressedalmostexclusivelyinendothelialcellsandfunctionstopromotenormaldevelopmentofthevascularsystem.
EGF-L7iscapableofantagoNISTicbindingtoNotchreceptorsresultingintheinhibitionofNotchsignalinginHUVECandneuralstemcells.Inresearchmodelsinducinghypoxiaandsubsequentreoxygenation,(H/R),EGF-L7caninhibitICAM-1expressionandenhancetheinhibitionofNF-kappaBactivation.Additionally,EGF-L7isachemoattractantforendothelialcellsandbindstotheextracellularmatrix.TheoverexpressionofEGF-L7isobservedinvariouscancers,andisgenerallycorrelatedwithincreasedmetastasisandapoorprognosis.
ThisantibodyreactswithhumanEGFL-7protein.
ELISA:useat1-10ug/ml.Immunoblotting:useat1-5ug/ml.Abandof~30kDaisdetected.
Immunohistochemistry:Useat2-10ug/ml.
Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.
Reconstituteindistilledwater.
Thisproductisstableforatleastone(1)yearat-20oCto-70oC.Reconstitutedproductshouldbestoredinappropriatealiquotstoavoidrepeatedfreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.