productdatasheet
Hsp90isahighlyconservedandessentialstressproteinthatisexpressedinalleukaryoticcells.Hsp90isinvolvedinthefolding,assembly,maturation,andstABIlizationofspecificproteinsasamemberofachaperonecomplex.Itisalsohighlyexpressedinunstressedcellswhereitparticipatesincontrollingtheactivity,turnover,andtraffickingofavarietyofproteins.MostoftheHsp90-regulatedproteinsareinvolvedincellsignalingandincludethekinases,v-Src,Wee1,c-Raf,transcriptionalregulatorssuchasp53andsteroidreceptors,andthepolymerasesofhepatitisBvirusandtelomerase.
Thisantibodyrecognizeshuman,rat,andmouseHsp90β.Itdoesnotcross-reactwithHsp90α.
Immunoblotting:useat1:20,000-1:40,000(ECL).Abandof~90kDaisdetected.
Positivecontrol:HeLacelllysate
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidrepeatedfreezingandthawing.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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