ORDERINGINFORMATION
CatalogNo.CloneNo.MAbSubtypeSize | LibraryPackNo.100ug/clone | ||||
19301 | LHRH13-327.8 | IgG1 | 100ug,500ug | 193101 | All4clones |
19302 | LHRH13-372.14 | IgG1 | 100ug,500ug | ||
19303 | LHRH13-387.5 | IgG1 | 100ug,500ug | ||
19304 | LHRH13-426.12 | IgG1 | 100ug,500ug | ||
Format:ProteinG-purifiedantibodyinPBS,pH7.4.
BACKGROUND
Gonadotropin-releasinghormone(GnRH),alsoknownasluteinizinghormone-releasinghormone(LHRH),isa10aminoacidneurohormoneproducedinthehypothalamus.GnRHstimulatesthesynthesisandsecretionofthetwogonadotropins—luteinizinghormone(LH)andfollicle-stimulatinghormone(FSH)—bytheanteriorpituitarygland.Characteristicofallreleasinghormones,andmoststrikinginthecaseofGnRH,isthephenomenonofpulsatilesecretion.
Undernormalcircumstances,GnRHisreleasedinpulsesatintervalsofabout90to120minutes.AbnormalitiesinthepulsatilesecretionofGnRHresultinsubnormalfertilityandabnormalorabsentmenstruation.ConstantadmiNISTrationofGnRHsuppressesgonadotropinsecretion,whichhastherapeuticbenefitsincertainpatients,suchaschildrenwithprecociouspubertyandmenwithprostatecancer.
SPECIFICATIONSUMMARY
Antigen:Purifiedhumangonadotropinreleasinghormone.
HostSpecies:Mouse
Specificity:TheseantibodiesrecognizehumanGnRH.
APPLICATIONS
TheseantibodieshavebeenqualifiedforuseinELISA,immunohistochemistry,andRIAtodetecthumanGnRH.Endusersshoulddetermineoptimalconcentrationsfortheirapplications.
RIA
CatalogNo.ngGnRHfor50%MAb
Displacement
193011.10
193022.70
193038.85
1930411.30
ImmunofluorescentdetectionofmouseGnRHneuronalcellswith#19304(Rajendren,GandGibson,MJ2001JNeuroendocrinology13:270).
DILUTIONINSTRUCTIONS
DiluteinPBSormediumthatisidenticaltothatusedintheassaysystem.
STORAGEANDSTABILITY
Theseantibodiesarestableforatleastone(1)yearat-20oCto-70oC.Storeproductinappropriatealiquotstoavoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
