productdatasheet

CatalogNo.:2415

Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.

Humanimmunodeficiencyvirus(HIV)andsimianimmunodeficiencyvirus(SIV)requirecoreceptorsinadditiontoCD4toinfecttargetcells.SomeGprotein-coupledreceptorsinthechemokinereceptorfamily,includingCCR5,CXCR4,CCR3,andCCR2b,

havepreviouslybeenidentifiedasHIVcoreceptors.AnorphanGprotein-coupledreceptordesignatedBonzowasrecentlyclonedandidentifiedasaHIV-1and-2andSIVcoreceptor(alsocalledSTRL33andTYMSTR).The

messengerRNAforBonzoisexpressedinlymphoidtissuesandactivatedperipheralbloodlymphocytes.

Antigen:Peptidecorrespondingtoaa319-338attheC-terminusofhumanBonzo.ThesequenceofthispeptideisidenticaltothoseofmacaqueandAfricangreenmonkey.

HostSpecies:Rabbit

StABIlizers:None

Preservatives:0.02%sodiumazide.

Thisantibodyrecognizesfull-lengthBonzo(40kD).

Immunoblotting:useat1:1,000dilution.Positivecontrol:WholecelllysatefromSW1353cells.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone

(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.