productdatasheet
CatalogNo.:1112
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.
Humanimmunodeficiencyvirus(HIV)andrelatedvirusesrequirecoreceptorsinadditiontoCD4toinfecttargetcells.SomeGprotein-coupledreceptorsincludingCCR5,CXCR4,CCR3,CCR2b,CCR8,GPR15,Bonzo,GPR1,
andV28,havebeenidentifiedasHIVcoreceptors.Amongthem,CCR5isaprincipalcoreceptorformacrophage-anddual-tropicHIV-1strains.CCR5isrequiredforinfectionbyHIV-1,HIV-2,andSIV.Theβ-chemokinesRANTES,MIP-1α,andMIP-1βaretheligandsforCCR5andpreventinfectionbymacrophage-tropicHIV-1.CCR5associateswiththesurfaceCD4-gp120ofHIVcomplexandleadstomembranefusionandvirusentryoftargetcells.
Theamino-terminaldomainandtheextracellularloopsofCCR5serveasHIVbindingsites.MessengerRNAforCCR5isexpressedinlymphoidcellsandtissues.
SPECIFICATIONSUMMARYAntigen:Peptidecorrespondingtoaa6-20ofhumanCCR5.
HostSpecies:Rabbit
StABIlizers:None
Preservatives:0.02%sodiumazide.
ThisantibodyrecognizeshumanCCR5(40kD).
Immunoblotting:useat1:1,000-1:2,000dilution.
Positivecontrol:WholecelllysatefromTHP-1cells.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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