CatalogNo.:15711

Size:500ugProteinG-purifiedantibodyinPBS,pH7.4.

Lipoteichoicacid(LTA)isthemajorproinflammatorystructurepresentwithinthecellwalllayerofmostgram-positivebacteria.Itplaysanimportantroleintheinitiationandprogressionofbacterialinfection,inflammation,andsepticshock.LTAinducesseveralcytokinesinvivo,andLTAandpeptidoglycan(PepG)synergizetocausetheinductionofnitricoxideformationwhichcanleadtomultipleorganfailure.

SinceLTAisalsofoundinthecellwallsofnon-pathogenicgram-positivebacteria,ithasbeensuggestedthatthestructureofLTA,anditsABIlitytosynergizewithPepG,determinestheabilityofaparticularbacteriumtocausesepticshock.

Antigen:Staphylococcusepidermidis,Haystrain(ATCC#55133).

HostSpecies:MouseAntibodyClass:IgG1Stabilizers:None

Preservatives:None.Availableonrequest.

ThisantibodyreactswithlipoteichoicacidofStaphepidermidis,Haystrain,aswellasclinicalstrainsofStaph.epidermidis(typesI,II,andIII),Staph.aureusstrains5and8,Strep.pyogenes,Strep.fecaelis,andStrep.mutans.Itdoesnotreactwithpeptido-glycanofStaph.aureusorpeptidoglycan-rhamnose,nordoesitreactwithpneumococcalpolysaccharides.Thisantibodydoesnotcross-reactwithE.colior

H.influenzaetypeB.

ELISA:useat0.1-1.0ug/ml(optimizedforLTAonsolidphase).

Opsonizationassay:useat80-160ug/ml(optimizedforStaph.epidermidis,Haystrain).

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.