ORDERINGINFORMATION

Format:*PEG-purifiedantibodyinPBS,pH7.4

**ProteinG-purifiedantibodyinPBS,pH7.4

BACKGROUND

Neisseriagonorrhoeaeisagram-negativecoccusandisthecauseofthesexuallytransmitteddiseasegonorrheawithhumansasitsonlynaturalhost.Althoughitdoesnotproduceanyexotoxins,Neisseriagonorrhoeaehasawiderangeofvirulencedeterminants.Thefirststagesofinfection,whichincludeadherenceandinvasion,aremediatedbysurfacecomponents;N.gonorrhoeaefirstattachestoepithelialcellsbymeansofitsfimbriae.Afterinitialattachment,thebacteriaenterasecondstageofbindingmediatedbytheoutermembraneproteinP.II(alsoknownasOpa)whichisneededfortightbindingandinvasionofepithelialcells.P.IIfromonebacteriumwillbindtolipooligosaccharideofanadjacentbacterium,whichallowsfortheconstructionofasmallcolonythatmayfunctionsimilarlytoabiofilm.NeisseriagonorrhoeaealsoproducesanIgA1proteasethatmaytakepartinthecolonizationstage.

SPECIFICATIONSUMMARY

Antigen:PoolofUV-inactivatedNeisseriagonorrhoeaecells:NeisseriaReferencelaboratorystrainsG-7,R-11,and7122(W-I),5766and8038(W-II),and8660(W-III).

HostSpecies:Mouse

Specificity:TheseantibodiesrecognizeN.gonorrhoeae.Theydonotcross-reactwithN.meningitides,N.cinerea,N.lactamica,N.sicca,B.catarrhalis,E.coli,ProteusmirABIlis,Gardnerellavaginalis,GroupBStrep.orChlamydiatrachomatis.

APPLICATIONS

TheseantibodieshavebeenqualifiedforuseinELISAtodetectN.gonorrhoeae.Endusersshoulddetermineoptimalconcentrationsfortheirapplications.

DILUTIONINSTRUCTIONS

DiluteinPBSormediumthatisidenticaltothatusedintheassaysystem.

STORAGEANDSTABILITY

Theseantibodiesarestableforatleastone(1)yearat-20oto-70oC.Storeproductinappropriatealiquotstoavoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notintendedforuseintherapeuticordiagnosticprocedures.