productdatasheet

CatalogNo.:11526(cloneS53-32)Size:100uginPBS,pH7.4;50%glycerol,0.09%sodiumazide.PurifiedbyProteinGaffinitychromatography.

IonchannelsareintegralmembraneproteinsthathelpestablishandcontrolthesmallvoltagegrADIentacrosstheplasmamembraneoflivingcellsbyallowingtheflowofionsdowntheirelectRochemicalgradient.BKchannelscontributetoelectricalimpulses,propersignaltransmission,andregulationofneurotransmitterrelease.ResearchsuggeststhatdistributionofthebetasubunitsinthebraincanmodulatetheBKchannelstocontributetothepatho-physiologyofepilepsyanddyskinesia.

Antigen:Fusionproteincorrespondingtoaa1-41(N-terminus)and218-235(C-terminus)ofmouseBKBeta2(accessionno.Q9CZM9).ThisN-terminalsequenceis97%homologouswithhumanandmouse.ThisC-terminalsequenceis100%homologouswithhumanandmouse.

HostSpecies:Mouse

AntibodyClass:IgG1

Thisantibodyrecognizeshuman,mouse,andratBKBeta2.Itdoesnotcross-reactwithBKBeta1,BKBeta3orBKBeta4.

Immunoblotting:useat1ug/ml.Abandof

~27kDaisdetected.ImmunohistochemistryandImmunocytochemistry:useat0.1-1ug/ml

Adultrathippocampus

Immunofluorescence:useat1-10ug/mlThesearerecommendedconcentrations.Usershoulddetermineoptimalconcentrationsfortheirapplication.

Positivecontrol:Adultratbrainlysate

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreezingandthawing.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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