productdatasheet

CatalogNo.:11528(cloneS40B-18)Size:100uginPBS,pH7.4;50%glycerol,0.09%sodiumazide.PurifiedbyProteinGaffinitychromatography.

IonchannelsareintegralmembraneproteinsthathelpestablishandcontrolthesmallvoltagegrADIentacrosstheplasmamembraneoflivingcellsbyallowingtheflowofionsdowntheirelectRochemicalgradient.BKchannelscontributetoelectricalimpulses,propersignaltransmission,andregulationofneurotransmitterrelease.ResearchsuggeststhatdistributionofthebetasubunitsinthebraincanmodulatetheBKchannelstocontributetothepatho-physiologyofepilepsyanddyskinesia.

Antigen:Fusionproteincorrespondingtoaa1-49(uniqueN-terminus)ofmouseBKBeta3a(accessionno.XP_989315).Thissequenceis86%homologouswithhumanBKBeta3a.

HostSpecies:Mouse

AntibodyClass:IgG1

Thisantibodyrecognizeshuman,mouse,andratBKBeta3a.ItdoesnotreactwithBKBeta1,Beta2,Beta3borBeta4.

Immunoblotting:useat1ug/ml.Abandof

~32kDaisdetected.

LysateofCOScellstransiently-transfectedwithBKBeta3aplasmidandprobedwith#11528.

ImmunohistochemistryandImmunocytochemistry:useat0.1-1ug/mlImmunofluorescence:useat1-10ug/mlThesearerecommendedconcentrations.Usershoulddetermineoptimalconcentrationsfortheirapplication.

Positivecontrol:Adultratbrainlysate

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreezingandthawing.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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