productdatasheet
CatalogNo.:56263
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.
AkirinisarecentlydiscoverednuclearproteinwithanessentialfunctionintheDrosophilamelanogasterimmunedeficiencypathwaywhichrespondstogram-negativebacterialinfection.Akirinisconservedinvertebratesasatleasttwogenesdesignatedakirin1andakirin2.Inmice,akirin2functionsintoll-liereceptor,tumornecrosisfactor,andinterleukin-1βsignalingpathwaysdownstreamofNF-κBtoinducethetranscriptionofseveralimmune-responsegenes.Inmice,knockoutofakirin1hadnoobviousphenotypiceffects,butknockoutofakirin2wasembryonic-lethal.
Antigen:Intermediatedomainpeptidesequence(14aminoacids)derivedfromhumanAkirin1(GenBankaccession
no.CAI16710).
HostSpecies:Rabbit
Preservatives:0.02%sodiumazide.
APPLICATIONSImmunoblotting:useat2ug/ml
Positivecontrol:Ratliverlysate.
WesternblotanalysisofAkirin1inratliverlysatewith#56263at2ug/ml(B).
Thisantibodyrecognizeshuman,mouse,andratAkirin1.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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