productdatasheet
CatalogNo.:56264
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.
AkirinisarecentlydiscoverednuclearproteinwithanessentialfunctionintheDrosophilamelanogasterimmunedeficiencypathwaywhichrespondstogram-negativebacterialinfection.Akirinisconservedinvertebratesasatleasttwogenesdesignatedakirin1andakirin2.Inmice,akirin2functionsintoll-liereceptor,tumornecrosisfactor,andinterleukin-1βsignalingpathwaysdownstreamofNF-κBtoinducethetranscriptionofseveralimmune-responsegenes.Inmice,knockoutofakirin1hadnoobviousphenotypiceffects,butknockoutofakirin2wasembryonic-lethal.
Antigen:N-terminaldomainpeptidesequence(16aminoacids)derivedfromhumanAkirin1(GenBankaccession
no.CAI16710).
HostSpecies:Rabbit
Preservatives:0.02%sodiumazide.
Immunoblotting:useat2ug/ml
Positivecontrol:A549celllysate.
WesternblotanalysisofAkirin1inA549
celllysatewith#56264at(A)1and(B)2ug/ml.
Thisantibodyrecognizeshuman,mouse,andratAkirin1.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
STORAGEANDSTABILITYThisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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