
Alpha-2CAdrenergicReceptorMonoclonalAntibody
PurifiedbyProteinGaffinitychromatography.
Thealpha-2Cadrenergicreceptor(alsoknownasADRA2C)controlsthereleaseofneurotransmittersfromcentraladrenergicneuronsandfromsympatheticnervesintheheart.
Therearethreesubtypesofthealpha-2adrenergicreceptor:alpha-2A,alpha-2B,andalpha-2C.Thehumanalpha-2Asubtypeundergoesphosphorylationandshort-termdesensitization,whereasthehumanalpha-2Csubtypeisnotphosphorylatedanddoesnotdesensitize.Thehumanalpha-2Csubtype,however,doesundergo
arrestin-dependentinternalization.Incontrasttoalpha-2Aandalpha-2Badrenergicreceptorsfromseveralspecies,thehumanalpha-2Creceptordoesnotappeartodown-regulateinresponsetoagoNISTtreatmentintransfectedcellculturesystems.
cytoplasmicC-terminus,ofhumanAlpha-2Cadrenergicreceptor(accessionno.P18825).
HostSpecies:MouseAntibodyClass:IgG1SPECIFICITYThisantibodyrecognizeshumanandmouseAlpha-2Cadrenergicreceptor.
Immunoblotting:useat1ug/ml.Predictedmolecularweightis~50kDaorlarger(possIBLyduetodimerization).
Thesearerecommendedconcentrations.Endusersshoulddetermineoptimalconcentrationsfortheirapplications.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notintendedfordiagnosticortherapeuticapplications.