
AmyloidBeta1-16(Aβ1-16)MonoclonalAntibody
CatalogNo.:57003(cloneAb3)Size:100uginPBS,pH7.4.PurifiedbyProteinGaffinitychromatography.
Accumulationandaggregationofamyloidβ(Aβ)inthebrainisindicatedasthetriggerofapathologicalcascadethatcausesAlzheimerdisease(AD).ThereisnowcompellingevidencethatmetalbindingtoAβisinvolvedinADpathogenesis.Theaminoacidregion1-16iswidelyconsideredasthemetalbindingdomainofAβ.Unlikecopper(II)thatpreferstheN-terminalaminogroupasthemainbindingsite,zinc(II)ispreferentiallyplacedinthe8-16aminoacidicregionofAβ(1-16).
Antigen:Syntheticpeptidecorrespond-ingtoAβ1-16.
HostSpecies:Mouse
AntibodyClass:IgG1
ThisantibodyrecognizesAβ1-16aswellasotherAβpeptides:Aβ37,Aβ38,Aβ39,Aβ40,andAβ42.NOTE:WhenadmiNISTeredtoyoungTg2576micewithminimalAβdepositionandtooldermicewithhigherAβloads,thisantibodyreducedAβaccumulationinthebrain.
APPLICATIONSImmunoblotting,Immunohistochemistry:Immunofluorescence,Immunoprecipitation,ELISA.Testat1-10ug/mlinallappli-cations.Thesearerecommendedconcentrations;endusershoulddetermineoptimalconcentrationsfortheirapplications.
Seespecificproductreferencesbelowformoreinformation.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.
LevitesYetal.2006.Anti-Aβ42andAnti-Aβ40specificmonoclonalantibodiesattenuateamyloiddepositioninanAlzheimer’sdiseasemousemodel.JClinInvest116:193-201.
LevitesYetal.2006.IntracranialAdeno-AssociatedVirus-MediatedDeliveryofAnti-PanAmyloidβ,Amyloidβ40,andAmyloidβ42Single-ChainVariableFragmentsAttenuatesPlaquePathologyinAmyloidPrecursorProteinMice.JNeurosci26:11923-11928.
LevitesYetal.2006.Insightsintothemechanismsofactionofanti-AβantibodiesinAlzheimer’sdiseasemousemodels.FASEBJ20:2576-8.
Forinvitroinvestigationaluseonly.Notintendedfordiagnosticortherapeuticapplications.