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CatalogNo.:2133

Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.

Accumulationoftheamyloid-βpeptide(Aβ)inthecerebralcortexisacriticaleventinthepathogenesisofAlzheimer'sdisease.

Theβ-amyloidproteinprecursor(APP)iscleavedby

β-secretase,producingasolublederivativeoftheproteinandamembraneanchored99-aminoacidcarboxy-terminalfragment(C99).TheC99fragmentservesassubstratefor

γ-secretasetogeneratethe4kDamyloid-βpeptidewhichisdepositedinthebrain.

Thisantibodyrecognizeshuman,mouse,andratAPPandAβpeptide.

Antigen:Peptidecorrespondingtoaa653-662ofhumanamyloidproteinprecursor(APP)oraa1-10ofthe4kDAβpeptidegeneratedbyβ-andγ-secretases.Thesequencesareidenticaltothoseofrabbit,pig,cow,guineapig,andchicken.

HostSpecies:Rabbit

StABIlizers:None

Preservatives:0.02%sodiumazide.

Immunoblotting:useat1:500-1:1,000dilution.

Positivecontrol:Mousebrainlysate.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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