productdatasheet
CatalogNo.:2136
Size:100ugIgGinPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.
Accumulationoftheamyloid-βpeptide(Aβ)inthecerebralcortexisacriticaleventinthepathogenesisofAlzheimer'sdisease.
Theβ-amyloidproteinprecursor(APP)iscleavedby
β-secretase,producingasolublederivativeoftheproteinandamembraneanchored99-aminoacidcarboxy-terminalfragment(C99).TheC99fragmentservesassubstratefor
γ-secretasetogeneratethe4kDamyloid-βpeptidewhichisdepositedinthebrain.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
SPECIFICATIONSUMMARYAntigen:Peptidecorrespondingtoaa737-751ofhumanamyloidproteinprecursor(APP)oraa85-99oftheC99fragmentgeneratedbyβ-secretasecleavage.Thesequencesareidenticaltothoseofmonkey,mouse,rat,chicken,andavarietyofotherspecies.
HostSpecies:Rabbit
StABIlizers:None
Preservatives:0.02%sodiumazide.
Thisantibodyrecognizeshuman,mouse,andratAPPandtheC99fragment.
Immunoblotting:useat1:500-1:1,000dilution.
Positivecontrol:Mousebrainlysate.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
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