productdatasheet
CatalogNo.:2249
Size:100ugIgGin200ulPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.
Accumulationoftheamyloid-βpeptide(Aβ)inthecerebralcortexisacriticaleventinthepathogenesisofAlzheimer'sdisease.
Aβpeptideisgeneratedasaresultofproteolyticcleavageoftheβ-amyloidproteinprecursor(APP)atβ-andγ-sites.β-secretasewasrecentlyidentifiedanddesignatedbeta-siteAPPcleavingenzyme(BACE)andaspartylprotease2(Asp2).ABACEhomologwasrecentlyidentifiedanddesignatedBACE2,orAsp1,DRAP(forDownregionasparticprotease),or
memapsin1.BACE2cleavesAPPattheβ-siteandatadifferentsitewithinAβ.
BACE2isfoundonchromosome21q223,the‘Downcriticalregion’,suggestingthatBACE2andAβmayalsocontributetothepathogenesisofDownsyndrome.
SPECIFICATIONSUMMARYAntigen:Peptidecorrespondingtoaa496-
511ofhumanBACE2.HostSpecies:RabbitStABIlizers:None
Preservatives:0.02%sodiumazide.
ThisantibodyrecognizeshumanBACE2(approx.75kD).
Immunoblotting:useat1:500-1:1,000dilution.
Positivecontrol:Humanhearttissuelysate.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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