productdatasheet
CatalogNo.:56465(cloneS96-55)Size:100uginPBS,pH7.4;50%glycerol,0.09%sodiumazide.PurifiedbyProteinGaffinitychromatography.
GABAisthemajorinhibitoryneuro-transmitterinthevertebratebrain.GABAreceptorsconsistoffivesubunitsthatformachlorideionchannel.Subunitfamiliesα,β,γ,andδhavebeenstudiedextensively;πandεhavebeenidentifiedrecently.
StudiesofrecombinantGABAreceptorshaveshownthatindividualsubunitsandtheirsubtypesconferdifferentsensitivitiestoGABAreceptormodulators.SubunitsubtypesaredifferentiallyexpressedthroughoutdevelopmentandindifferentCNSregions,reducingthetotalnumberofpossIBLeisoformsthatcanbeformedindifferentbrainregionsandinindividualcells.
SPECIFICATIONSUMMARYAntigen:Fusionprotein,aa327-450ofmouseBeta1GABA-Areceptor(accessionno.P50571).HostSpecies:MouseAntibodyClass:IgG1Thisantibodyrecognizeshuman,mouse,andratBeta1GABA-Areceptor.Itdoesnotcross-reactwithBeta2orBeta3GABA-Areceptors.
APPLICATIONSImmunoblotting:useat1-10ug/ml.Abandof~55kDaisdetected.
AdultratbrainlysateImmunohistochemistryandImmunocytochemistry:useat0.1-1ug/mlImmunofluorescence:useat1-10ug/mlThesearerecommendedconcentrations.Usershoulddetermineoptimalconcentrationsfortheirapplication.
Positivecontrol:Ratbrainlysate.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreezingandthawing.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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