ADVANCEDRESEARCHTECHNOLOGIES
CatalogNo.:56482(cloneS87-25)Size:100uginPBS,pH7.4;50%glycerol,0.09%sodiumazide.PurifiedbyProteinGaffinitychromatography.
BACKGROUNDIonchannelsareintegralmembraneproteinsthathelpestablishandcontrolthesmallvoltagegrADIentacrosstheplasmamembraneoflivingcellsbyallowingtheflowofionsdowntheirelectRochemicalgradient.Insomeionchannels,theflowofionsisgovernedbyagatewhichiscontrolledbychemicalorelectricalsignals,temperature,ormechanicalforces.TheGABA-Areceptorisafastactingligand-gatedionchannel.GABA-Areceptorsarethemajorfastinhibitoryneurotransmittergatedionchannelsinthebrain.
Antigen:Fusionproteincorrespondingtoaa370-433ofmouseBeta3GABA-Areceptor(accessionno.AAB60502).
HostSpecies:Mouse
AntibodyClass:IgG1
Thisantibodyrecognizeshuman,mouse,andratBeta3GABA-Areceptor.Itdoesnotcross-reactwithBeta1or2GABA-Areceptor.
Immunoblotting:useat1-10ug/ml.Abandof~55kDaisdetected.
Adultratbrainmembrane
Immunohistochemistry:useat1-10ug/mlThesearerecommendedconcentrations.Usershoulddetermineoptimalconcentrationsfortheirapplication.
Positivecontrol:Ratbrainlysate.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreezingandthawing.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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