ORDERINGINFORMATION
Catalognos.:56336-50(50ug)56336-200(200ug)
Format:ProteinA-purifiedantibodyinPBS,50%glycerol,0.09%sodiumazide,.
BACKGROUND
CalcineurinisaCa+2/calmodulin-dependentserine/threonineproteinphosphatase.TheactiveenzymeisaheterodimerconsistingofacatalyticAsubunitandamyristylatedregulatoryBsubunitthatbindscalcium.ItcontrolsthetranslocationofnuclearfactorsfromthecytosolintothenucleusofactivatedTcells.CalcineurinisatargetofimmunosuppressivedrugssuchascyclosporinAandFK506.
SPECIFICATIONSUMMARY
Antigen:Syntheticpeptidecorrespondingtoaa264-283ofhumanCalcineurinAconjugatedtoKLH.ThissequenceisidenticalinratandmousecalcineurinA.
Accessionno.:P16298
GeneID:5532
HostSpecies:Rabbit
AntibodyClass:Polyclonal
Specificity:Thisantibodyrecognizeshuman,mouse,rat,rabbit,canine,bovine,porcine,chicken,monkey,hamster,andDrosophilaCalcineurinA.
APPLICATIONS
Immunoblotting:Useat1-5ug/ml.Abandof~61kDaisdetected.
DetectionofCalcineurinAinratbrainlysate(Lane1)andmousebrainlysate(Lane2).
Thesearerecommendedconcentrations.Endusersshoulddetermineoptimalconcentrationsfortheirapplication.
DILUTIONINSTRUCTIONS
DiluteinPBSormediumthatisidenticaltothatusedintheassaysystem.
STORAGEANDSTABILITY
Thisantibodyisstableforatleastone(1)yearat-20oC.Storeinappropriatealiquotstoavoidmultiplefreeze/thawcycles.
Forinvitroinvestigationaluseonly.Notintendedfortherapeuticordiagnosticprocedures.
