productdatasheet
CatalogNo.:56470(cloneS18-30)Size:100uginPBS,pH7.4;50%glycerol,0.09%sodiumazide.PurifiedbyProteinGaffinitychromatography.
Chapsyn-110isamemberofthemembrane-associatedputativeguanylatekinase(MAGUK)family.ItbindsdirectlytotheNMDAreceptorandShakerK+
channelsubunitsandis70-80%identicaltoPSD-95/SAP90andSAP97.It
mediatesclusteringofbothNMDAreceptorsandK+channelsinheterologouscells.Theencodedproteinformsa
heterodimerwithPSD-95thatmayinteractatpostsynapticsitestoformamultlimericscaffoldfortheclusteringofreceptors,ionchannels,andassociatedsignalingproteins.
Thisantibodyrecognizeshuman(weak),mouse,andratChapsyn-110.ItdoesnotreactwithPSD-95,SAP97,orSAP102.
APPLICATIONSImmunoblotting:useat1-10ug/ml.Abandof~110kDaisdetected.
Adultratbrainmembranesprobedwith#56470
ImmunohistochemistryandImmunocytochemistry:useat0.1-1ug/mlImmunofluorescence:useat1-10ug/mlThesearerecommendedconcentrations.Usershoulddetermineoptimalconcentrationsfortheirapplication.
Positivecontrol:Ratbrainlysate.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone(1)yearat-20oC.Avoidrepeatedfreezingandthawing.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
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