productdatasheet
CatalogNo.:28115
Size:100ugantigenaffinity-purifiedantibodyinPBS,pH7.4.
SPECIFICATIONSUMMARYAntigen:Syntheticpeptidecorrespondingtoaa430-445oftheNC3regionofhumanandmouseCLAC-P.HostSpecies:Rabbit
AntibodyClass:PolyclonalPreservatives:None.Availableonrequest.
BACKGROUNDAlzheimer’sdisease(AD)ischaracterizedbydepositionofβ-amyloidassenileplaquesandcerebralamyloidangiopathy.TheprincipalcomponentofADamyloidistheamyloidβpeptide(Aβ).AlthoughproductionanddepositionofAβappearcloselyrelatedtothepathogenesisofAD,currentevidencesuggestthatAβaloneisnotsufficienttocauseneuronaldeathandsymptomsofdementia.Acomponentofsenileplaque(SP),CLAC(collagen-likeAlzheimeramyloidplaquecomponent)anditsprecursorCLAC-Paredepositedwithextracellularβ-amyloidandhavebeenrecentlyimplicatedincelltoxicityofβ-amyloidinADbrains.CLAC-Pisaunique,membrane-boundcollagen-likestructurecontainingthreeGly-X-Yrepeatmotifsandmaydefineanovelclassofneuronalcollagens.
SPECIFICITYThisantibodyrecognizesnativeandhumanandmouseCLAC-P.
Immunoblotting:at2-5ug/ml,abandofapprox.70kDaisdetectedinHEK293celllysate.
Immunohistochemistry(paraffin):at5-10ug/ml,positivestainingofsenileplaquesinADbrains.
Thesearerecommendedconcen-trations.Usershoulddetermineoptimalconcentrationsfortheirapplications.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisantibodyisstableforatleastone
(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseindiagnosticortherapeuticprocedures.
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