EAAC1MonoclonalAntibody
CatalogNo.:56520(cloneS180-41)Size:100uginPBS(1mg/ml),pH7.4,50%glycerol,0.09%sodiumazide.
PurifiedbyProteinGaffinitychromatography.
Excitatoryamino-acidcarrier1(EAAC1)isahigh-affinityNa+-dependentL-glutamate/D,L-aspartatecellmembranetransportprotein.Itisexpressedinbrain
aswellasinseveralnon-nervoussystemtissues.Inbrain,EAAC1istheprimaryneuronalglutamatetransporter.Ithasapolarizeddistributionincellsandfunctionsmainlyperisynapticallytotransportglutamatefromtheextracellularenvironment.Inthekidneyitisinvolvedinrenalacidicaminoacidreabsorptionandaminoacidmetabolism.EAAC1-associatedproteinGTRAP3-18maybeimportantinregulatingthemetabolicfunctionofEAAC1.
Antigen:Fusionproteincorrespondingtoaa1-524(full-length)ofhumanEAAC1(accessionno.NP_004161.4).
HostSpecies:Mouse
AntibodyClass:IgG1
SPECIFICITYThisantibodyrecognizeshumanEAAC1.
Immunoblotting:useat1-5ug/ml.Abandof~60kDaisdetected.
Immunoblotonratbrainmembranes.
Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.
Positivecontrol:ratbrainmembranes.
DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.
Thisproductisstableforatleast1yearat
-20oC.Freezeinmultiplealiquotstoavoidrepeatedfreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.
